Author

Pia Weikop

University of CopenhagenORCID 0000-0002-8422-1702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:electronic health records· 2 Assay:imaging· 2 Research Focus:spatial domain detection· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Maiken NedergaardiD· 4 shared Celia KjærbyiD· 2 shared Elise Schiøler NielseniD· 2 shared Eszter Rebeka KovacsiD· 2 shared Mie AnderseniD· 2 shared Yulong LiiD· 2 shared Anastasia Tsopanidou· 1 shared Anders Fink‐JenseniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersNeuroscience

Maiken NedergaardORCID

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Author profile →

6 papers

Recent·Most cited

Multimodal imaging maps spinal glymphatic transport in health and its disruption after injury

Jaspreet Kaur, Michael J. Giannetto, Devin T Wong, Douglas H. Kelley, Pia Weikop, Maiken Nedergaard

This study maps glymphatic transport in the spinal cord using imaging and shows that it is disrupted after injury, with impaired clearance and worsened outcomes in AQP4-knockout mice.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

Coordinated infraslow cortical oscillations of neuromodulators during NREM sleep

Celia Kjærby, Tessa Radovanovic, Eszter Rebeka Kovacs, Zuzanna Bojarowska, Klaudia Tokarska, Anastasia Tsopanidou, Elise Schiøler Nielsen, Mie Andersen, Yulong Li, Pia Weikop, Verena Untiet, Maiken Nedergaard

The paper investigates coordinated infraslow cortical oscillations of multiple neuromodulators during NREM sleep in mice and finds they are regulated by specific neural circuits.

iScience · Dec 29, 2025Peer-reviewedNeuroscience

Glymphatic clearance is enhanced during sleep

Erik Kroesbergen, Laurence V. Riesselmann, Ryszard S. Gomolka, Virginia Plá, Tina Esmail, Visti Hildebrandt Stenmo, Eszter Rebeka Kovacs, Elise Schiøler Nielsen, Steven A. Goldman, Maiken Nedergaard, Pia Weikop, Yuki Mori

This study shows glymphatic clearance is increased during sleep and anesthesia and reduced during wakefulness, with tracer dose adjustments needed for accurate comparison across brain states.

bioRxiv · Aug 24, 2024 · PreprintNeuroscience

Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions

Celia Kjærby, Mie Andersen, Natalie Linea Hauglund, Fengfei Ding, Wei Wang, Qiwu Xu, Ning Kang, Sisi Peng, Qian Sun, Camilla Dall, Peter Kusk Jørgensen, Jiesi Feng, Yulong Li, Pia Weikop, Hajime Hirase, Maiken Nedergaard

This study investigates how locus coeruleus-norepinephrine system activity and astrocytic responses change during sleep states, revealing dynamic fluctuations in norepinephrine levels and their relationship to sleep processes.

Nature Neuroscience · Jul 7, 2022Peer-reviewedNeuroscience

Disrupted PDZ-domain binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis and reward motivation

Gunnar Sørensen, Mattias Rickhag, Damiana Leo, Matthew Domenic Lycas, Pernille Herrstedt Ridderstrøm, Pia Weikop, Freja Herborg, David P.D. Woldbye, Gitta Wörtwein, Raul R. Gainetdinov, Anders Fink‐Jensen, Ulrik Gether

This study shows that disrupting the PDZ-domain binding motif of the dopamine transporter alters its nanoscale distribution and dopamine homeostasis, leading to changes in reward-related behaviors.

bioRxiv · Jan 6, 2021 · PreprintNeuroscience

Muscarinic M1 receptor stimulation prevents and reverses addiction-related effects of cocaine

Pia Weikop, Kathrine Louise Jensen, Morgane Thomsen

This study shows that M1 receptor agonist VU0364572 prevents and reverses cocaine addiction-related behaviors in rats, with lasting effects on dopamine and glutamate signaling.

Neuropsychopharmacology · Apr 28, 2020Peer-reviewedNeuroscience