Can Martin Zhang

The paper discovers abundant nanoscale lymphatic-like vessels in brain parenchyma of mice and humans, suggesting a previously unrecognized system for metabolic waste clearance.

This paper introduces a chemiluminescence probe, ADLumin-1, that enables both generic and precise detection of misfolded proteins in neurodegenerative disease models.

This study identifies multi-copper oxidases (MCOs) as enzymes capable of degrading amyloid beta (Aβ) peptides, with ascorbate oxidase showing the strongest effect, and demonstrates their potential to mitigate Aβ-induced neuronal toxicity.

This paper identifies HUWE1 as a ubiquitin ligase that enhances ubiquitin modifications on proteins and aggregates, promoting their degradation via proteasome and autophagy pathways.

This paper develops a platform combining graphene-assisted Raman spectroscopy and machine learning to rapidly screen Alzheimer's disease biomarkers in mouse brains, achieving 98% classification accuracy.

This paper demonstrates the use of bioluminescence imaging with AkaLumine to report amyloid beta levels in Alzheimer's disease models and shows its potential for monitoring disease progression and therapy.