Molecular BiologybioRxivPreprint
HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates
Mengying Zhou, Rui Fang, Louis Colson…·Ying Lu
This paper identifies HUWE1 as a ubiquitin ligase that enhances ubiquitin modifications on proteins and aggregates, promoting their degradation via proteasome and autophagy pathways.
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