Author

Michael Frochaux

SIB Swiss Institute of BioinformaticsORCID 0000-0002-4347-5562Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Bart DeplanckeiD· 3 shared Abhishek Kumar MishraiD· 1 shared Armin HuberiD· 1 shared Claire-Emmanuelle Indelicato· 1 shared Cornelia FritschiD· 1 shared Dali Ma· 1 shared F. Javier Bernardo-GarciaiD· 1 shared François LeulieriD· 1 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersDevelopmental Biology

Bart DeplanckeORCID

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3 papers

Recent·Most cited

Commensal bacteria act as a broad genetic buffer in Drosophila during chronic under-nutrition

Dali Ma, Maroun S. Bou Sleiman, Pauline Joncour, Claire-Emmanuelle Indelicato, Michael Frochaux, Virginie Braman, Maria Litovchenko, Gilles Storelli, Bart Deplancke, François Leulier

This study shows that the Drosophila facultative symbiont Lactobacillus plantarum buffers genetic variation under chronic under-nutrition, reducing phenotypic and gene expression variation.

iScience · Aug 2, 2019Peer-reviewedDevelopmental Biology

Selection against expression noise explains the origin of the hourglass pattern of Evo-Devo

Jialin Liu, Michael Frochaux, Vincent Gardeux, Bart Deplancke, Marc Robinson‐Rechavi

The paper investigates the hourglass pattern of Evo-Devo by showing reduced expression variability during the phylotypic stage in Drosophila melanogaster, linked to histone modification-mediated noise control.

bioRxiv · Jul 13, 2019 · PreprintEvolutionary Biology

Multilevel regulation of the glass locus during Drosophila eye development

Cornelia Fritsch, F. Javier Bernardo-Garcia, Tim‐Henning Humberg, Abhishek Kumar Mishra, Sara Miellet, Silvia Almeida, Michael Frochaux, Bart Deplancke, Armin Huber, Simon G. Sprecher

The paper identifies complex regulatory mechanisms controlling glass locus expression in Drosophila eye development, including cis-acting elements and an alternative small open reading frame.

PLoS Genetics · Jul 12, 2019Peer-reviewedDevelopmental Biology