François Leulier

OrganScaleR provides a Shiny tool for size-adjusted organ-weight analysis in mice, avoiding misleading ratios by using ANCOVA or causal mediation based on body-weight overlap.

This study shows that prophage induction in Lactiplantibacillus plantarum releases extracellular vesicles that support host growth during nutritional stress.

The paper identifies an interaction network involving DltD, DltX, and DltE that regulates LTA D-alanylation in L. plantarum, which promotes Drosophila growth.

The paper shows that Lactiplantibacillus plantarum enhances midgut growth in Drosophila larvae under malnutrition via Ecdysone signaling, revealing a microbiota-driven mechanism for developmental plasticity.

The paper identifies Limostatin as a nutrient-sensitive enterokine that coordinates developmental plasticity in Drosophila larvae through inter-organ signaling.

This study examines the effects of semaglutide on growth and metabolism in juvenile mice, finding it lowers blood glucose in normally growing mice but worsens growth impairment in stunted juveniles.

This study shows that juvenile protein restriction in mice reduces sexual dimorphism by affecting somatic growth, energy metabolism, and hepatic molecular identity, with distinct adaptations in reproductive development.

This study shows that suboptimal refeeding diets can restore body length but impair glucose metabolism in male mice with early-life malnutrition, while optimal refeeding fully restores growth in females.

This study shows that a Western diet with protein restriction in juvenile mice causes metabolic dysregulation without obesity, including hyperglycemia and fatty liver.

This study shows that the Drosophila facultative symbiont Lactobacillus plantarum buffers genetic variation under chronic under-nutrition, reducing phenotypic and gene expression variation.

This study shows that gut microbiota changes induced by chronic stress affect depressive-like behaviors and adult hippocampal neurogenesis through the endocannabinoid system in mice.

This study introduces a CRISPR-Cas9-based genome editing method for Lactobacillus plantarum without requiring recombinase, showing it can efficiently introduce stop codons and deletions but with some unexpected outcomes.