Simon G. Sprecher

This study investigates the sensory responses of the acoel Symsagittifera roscoffensis to chemical and temperature stimuli, finding avoidance behaviors to increased temperature and high salinity.

This study shows Ataxin-2 is required in Kenyon cells for mRNP granule assembly and appetitive long-term memory formation in Drosophila.

The paper investigates how gustatory organs contribute to food texture preference in Drosophila larvae, showing their role in texture evaluation and ingestion decisions.

This study shows that Dop1R2 is required for later memory forms but not short-term memories in Drosophila, with specific spatial requirements in the Mushroom body lobes.

The paper identifies memory phase-specific genes in Drosophila mushroom bodies using a CREB-DamID approach and validates them through RNAi screens.

This study uses single-cell transcriptomics to characterize cell types in the squid Loligo vulgaris and identifies key markers for major nervous system components.

The paper assembles and annotates the genome of Symsagittifera roscoffensis to study its phylogenetic position and molecular mechanisms of symbiosis.

The paper identifies Homothorax as a regulator controlling a binary rhodopsin switch in Drosophila ocelli, promoting Rh2 and repressing Rh1 expression.

This paper presents alternative models for predictive olfactory learning in Drosophila, challenging traditional associative plasticity models and offering a framework to interpret DAN activity during learning.

This study uses single-cell transcriptomics to identify ten major cell-type categories in the acoel Isodiametra pulchra, revealing both shared and clade-specific molecular markers.

The paper investigates multimodal and multisensory coding in Drosophila larval taste neurons using calcium imaging and single-cell transcriptomics, revealing complex integration of taste and mechanical stimuli.

The paper identifies how temporal control of inhibition via muscarinic acetylcholine receptor signaling generates ON and OFF selectivity in Drosophila larval visual circuits without anatomical segregation.

The paper identifies complex regulatory mechanisms controlling glass locus expression in Drosophila eye development, including cis-acting elements and an alternative small open reading frame.

The paper investigates whether the transcription factor Glass, essential for rhabdomeric photoreceptor formation in Drosophila, plays a similar role in other metazoans.

The paper identifies a molecular basis for carbonation detection using Drosophila IRs, showing that Ir56d, along with co-receptors, is essential for carbonation and fatty acid sensing.

The paper develops a stochastic model of Drosophila larval phototaxis using light intensity and directionality, showing larvae minimize light exposure while maximizing distance from the light source.

The paper identifies genes regulating long-term memory in Drosophila by profiling transcriptomic changes in mushroom bodies and testing candidate genes via RNAi knockdown.

The paper characterizes bHLH transcription factors in the acoel S. roscoffensis and identifies their roles in neurogenesis.

This paper maps the synaptic wiring diagram and neurotransmitters of the Drosophila larval visual circuit, revealing parallel circuits for light intensity and temporal changes.