Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytes
Ilhan Gokhan, Xia Li, Jack M Sendek, Alex J. Mora Pagan, Fadi G. Akar, Stuart G. Campbell
This study shows that desmoplakin loss causes PKC-dependent sarcomere shortening and contractile dysfunction in cardiomyocytes, leading to heart failure.
bioRxiv · May 15, 2025 · PreprintPhysiology