Commensal-derived Trehalose Monocorynomycolate Triggers γδ T Cell-driven Protective Ocular Barrier Immunity
Xiaoyan Xu, Yannis Rigas, Mary Joseph Mattapallil, Jing Guo, Keiko Sakamoto, Keisuke Nagao, Vijayaraj Nagarajan, Eric Bohrnsen, Crystal L. Richards, Akriti Gupta, Guillaume Gaud, Paul E. Love, Timothy Jiang, Amy Zhang, Biying Xu, , Rachel R Caspi
This paper identifies trehalose monocorynomycolate (TMCM) from C. mast as a stimulator of IL-17-producing γδ T cells at the ocular surface, which protects against corneal infection.
Immunity · Jan 19, 2026Peer-reviewedImmunology