Bernard Choi

CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo

This study identifies CDC42 inhibitors that reduce vessel branching in both normal skin and tumors, offering potential for treating skin cancer and angiogenesis-related diseases.

High-speed quantitative optical imaging of absolute metabolism in the rat cortex

This paper introduces a method to measure absolute cerebral metabolic rate of oxygen in rat brains using optical imaging techniques and validates it against MR and PET measurements.

Cerebral perfusion and metabolism coupling during a critical time window provides rapid assessment of cardiac arrest severity and prognosis in a preclinical model

The paper measures cerebral perfusion and metabolism metrics post-cardiac arrest in rats to assess severity and prognosis, finding that CBF/CMRO2 ratio at 1 min post-resuscitation predicts neurological recovery with 87% accuracy.

Spreading depolarization and repolarization during cardiac arrest as an ultra-early marker of neurological recovery in a preclinical model

The paper characterizes spreading depolarization and repolarization during cardiac arrest in a rodent model and links their timing to neurological recovery outcomes.