Nigel H. Greig

Dissociated adult mouse sinoatrial node cultures stay spontaneously electrically active beyond ten days on MEA arrays and, on compliant hydrogels, permit live tracking of heterogeneous S100B-EGFP-labeled cells.

This paper evaluates 3MP, a novel immunomodulator, showing it reduces alpha-Synuclein aggregation and microglial inflammation in vitro and in vivo, offering a dual-target therapeutic approach for Parkinson's disease.

This study identifies microglia as the primary source of TGF-β1 ligand in the adult mouse brain, showing its role in maintaining microglial homeostasis and cognitive function through an autocrine mechanism.

This study shows GLP-1R agonism improves Parkinson's disease by restoring neuronal insulin signaling and reducing glial inflammation, with clinical benefits in patients with higher baseline MAPK expression.

The paper shows that microglia in specific brain regions exhibit premature aging-related inflammation in middle age, which may affect nearby neurons.

This study shows that astrocytic extracellular vesicles can accelerate spontaneous recovery after stroke in rats by promoting anatomical and functional recovery.