This study compares the effects of BCG-Russia and BCG-TICE on trained immunity in mice, finding BCG-TICE induces stronger innate immune memory and inflammation-related gene expression.

PLoS ONE · Sep 11, 2026Peer-reviewedImmunology

Failure of Bacillus Calmette-Guerin Therapy in Patients with Bladder Cancer is Characterized by Immune Dysfunction Associated with Activator Protein 1

Andrew Garven, Jean‐François Paré, Alexandra Robins, Ana Vera-Rodríguez, Rohan Sampy, Arianna Bennett, Richard W. Nauman, Andrew W. Craig, Peter A. Greer, Madhuri Koti, Tiziana Cotechini, David Monty Berman, Amber Simpson, Lynne-Marie M Postovit, D. Robert Siemens, Charles H. Graham

This study identifies immune dysfunction linked to AP-1 in BCG non-responders with NMIBC, suggesting pre-existing immunosenescence contributes to early recurrence.

bioRxiv · May 10, 2026 · PreprintCancer Biology

Transgenerational impact of aberrant inflammation in rat pregnancy

Takafumi Ushida, Tiziana Cotechini, Nicole Protopapas, Aline Atallah, Charlotte Collyer, Shannyn K. Macdonald-Goodfellow, Man Yat Tse, Louise M. Winn, Stephen Ching-ng Pang, Michael A. Adams, Maha Othman, Tomomi Kotani, Hiroaki Kajiyama, Charles H. Graham

This study shows that maternal inflammation during pregnancy can lead to transgenerational risks of cardiovascular and metabolic diseases in offspring.

bioRxiv · Nov 9, 2021 · PreprintDevelopmental Biology