Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins in the Human Malaria Parasite Plasmodium falciparum
Timothy J. Russell, Erandi K. De Silva, Valerie M. Crowley, Kathryn Shaw‐Saliba, Namita Dube, Gabrielle A. Josling, Charisse Flerida A. Pasaje, Irene A. Kouskoumvekaki, Gianni Panagiotou, Jacquin C. Niles, Marcelo Jacobs‐Lorena, C. Denise Okafor, Francisco‐Javier Gamo, Manuel Llinás
The paper identifies antimalarial compounds that inhibit ApiAP2 proteins in Plasmodium falciparum by screening small molecules against the AP2-EXP domain and validating their effects on parasite gene regulation and growth.
bioRxiv · Apr 5, 2022 · PreprintMolecular Biology