Gianni Panagiotou

This study validates an alveolar-like macrophage model as a physiologically relevant in vitro system for studying early Aspergillus fumigatus infection dynamics.

The paper shows that plant glucosinolates select for bacterial communities with redundant and cooperative metabolic functions in wild Arabidopsis leaves.

This study shows that M-CSF enhances alveolar macrophage function to protect against invasive aspergillosis in immunocompromised mice.

This study shows the murine lung microbiome is dynamic and transient, with bacteria rapidly cleared by the immune system and not establishing stable colonization.

This study identifies SmpR as a transcription factor that coordinates secondary metabolism and antibacterial defense in A. fumigatus in response to bacterial signals.

This study identifies Leptotrichia wadei as a pro-tumorigenic bacterium in CRC by linking metabolic specialization to microbial niches and tumor progression.

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.

This study investigates how HCMV and its virokine CMVIL-10 modulate dendritic cell responses during co-infection with A. fumigatus, revealing that CMVIL-10 has a limited role in suppressing antifungal immunity.

This study shows that Aspergillus fumigatus infection in immunosuppressed mice disrupts lung microbiome balance, increasing anaerobic bacteria like Ligilactobacillus murinus, which can be internalized by epithelial cells.

The paper identifies antimalarial compounds that inhibit ApiAP2 proteins in Plasmodium falciparum by screening small molecules against the AP2-EXP domain and validating their effects on parasite gene regulation and growth.

DAnIEL provides a web server for analyzing fungal ITS amplicon sequencing data, offering data processing, statistical analysis, and comparison with public datasets.