Transient Maternal IL-6 boosts glutamatergic synapses and disrupts hippocampal connectivity in the offspring
Filippo Mirabella, Genni Desiato, Sara Mancinelli, G Fossati, Marco Rasile, Raffaella Morini, Marija Markicevic, Christina Grimm, Clara A. Amegandjin, Alberto Termanini, Clelia Peano, Paolo Kunderfranco, Graziella Di Cristo, Valerio Zerbi, Simona Lodato, , Davide Pozzi
The paper shows that transient maternal IL-6 elevation during early neurodevelopment disrupts hippocampal connectivity and enhances glutamatergic synapses in offspring through the STAT3/RGS4 pathway.
bioRxiv · Nov 2, 2020 · PreprintNeuroscience