Author

Christina Grimm

University of ZurichORCID 0000-0002-2379-4160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Valerio ZerbiiD· 4 shared Nicole WenderothiD· 3 shared Daniel RazanskyiD· 2 shared Johannes BohacekiD· 2 shared Marija MarkiceviciD· 2 shared Stefan FrässleiD· 2 shared Alberto TermaniniiD· 1 shared Alessandro GozziiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Valerio ZerbiORCID

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4 papers

Recent·Most cited

Functional-based parcellation of the mouse prefrontal cortex for network perturbation analysis

Iurii Savvateev, Christina Grimm, Marija Markicevic, Joanes Grandjean, David Sastre-Yagüe, Alessandro Gozzi, Nicole Wenderoth, Rafael Hernán Polanía, Valerio Zerbi

The paper uses functional connectivity to parcellate the mouse prefrontal cortex and shows that perturbing specific clusters affects only their associated functional networks.

Cell Reports · Apr 25, 2025Peer-reviewedNeuroscience

Locus Coeruleus firing patterns selectively modulate brain activity and dynamics

Christina Grimm, Sian N. Duss, Mattia Privitera, Brandon Munn, Stefan Frässle, Maria Chernysheva, Tommaso Patriarchi, Daniel Razansky, Nicole Wenderoth, James M. Shine, Johannes Bohacek, Valerio Zerbi

This study shows that tonic and burst firing patterns of the locus coeruleus modulate brain activity and dynamics in mice through distinct mechanisms.

bioRxiv · Aug 29, 2022 · PreprintNeuroscience

Optogenetic Activation of Striatal D1/D2 Medium Spiny Neurons Differentially Engages Downstream Connected Areas Beyond the Basal Ganglia

Christina Grimm, Stefan Frässle, Céline Steger, Lukas von Ziegler, Oliver Sturman, Noam Shemesh, Daria Peleg‐Raibstein, Denis Burdakov, Johannes Bohacek, Klaas Enno Stephan, Daniel Razansky, Nicole Wenderoth, Valerio Zerbi

This study uses optogenetics and fMRI to show that D1 and D2 MSNs in the striatum differentially activate brain regions beyond the basal ganglia, revealing complex functional interactions.

bioRxiv · Mar 23, 2021Neuroscience

Transient Maternal IL-6 boosts glutamatergic synapses and disrupts hippocampal connectivity in the offspring

Filippo Mirabella, Genni Desiato, Sara Mancinelli, G Fossati, Marco Rasile, Raffaella Morini, Marija Markicevic, Christina Grimm, Clara A. Amegandjin, Alberto Termanini, Clelia Peano, Paolo Kunderfranco, Graziella Di Cristo, Valerio Zerbi, Simona Lodato, , Davide Pozzi

The paper shows that transient maternal IL-6 elevation during early neurodevelopment disrupts hippocampal connectivity and enhances glutamatergic synapses in offspring through the STAT3/RGS4 pathway.

bioRxiv · Nov 2, 2020 · PreprintNeuroscience