Author

Denis Tempé

Centre National de la Recherche ScientifiqueORCID 0000-0002-4684-3033Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Guillaume BossisiD· 2 shared Guillaume CartroniD· 2 shared Ludovic GabellieriD· 2 shared Chamseddine KifagiiD· 1 shared Charlotte Andrieu‐SoleriD· 1 shared Delphine GitenayiD· 1 shared Élise GuéretiD· 1 shared Éric SoleriD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Guillaume BossisORCID

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2 papers

Recent·Most cited

The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid Leukemias.

Rawan Hallal, Marion de Toledo, Denis Tempé, Rayane Berrahouane, Sara Zemiti, Loïs Coënon, Delphine Gitenay, Simon George, Moritz Schüssler, Nadine Laguette, Sarah Bonnet, Ludovic Gabellier, Guillaume Cartron, Mireia Pelegrín, Martín Villalba, Guillaume Bossis

This paper shows that TAK-981 activates NK cells against AML by inducing IFN-I secretion, enhancing their cytotoxicity and cytokine production.

Molecular Cancer Therapeutics · Jul 15, 2025Peer-reviewedCancer Biology

SUMOylation controls the rapid transcriptional reprogramming induced by anthracyclines in Acute Myeloid Leukemias

Mathias Boulanger, Chamseddine Kifagi, Marko Ristic, Ludovic Gabellier, Denis Tempé, Jón Otti Sigurðsson, Tony Kaoma, Charlotte Andrieu‐Soler, Thierry Forné, Éric Soler, Yosr Hicheri, Élise Guéret, Laurent Vallar, Jesper Velgaard Olsen, Guillaume Cartron, , Guillaume Bossis

This study shows that Daunorubicin induces transcriptional changes in AML cells through SUMO-dependent chromatin reconfiguration, affecting genes related to proliferation, death, and immunity.

bioRxiv · Apr 19, 2022 · PreprintMolecular Biology