Author

Alessia Sciortino

University of LuxembourgORCID 0009-0005-8770-3490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Manuel ButtiniiD· 4 shared Pierre GarciaiD· 4 shared Kristopher J. SchmitiD· 3 shared Michel Guy André MittelbronniD· 3 shared Rashi HalderiD· 3 shared Lasse SinkkoneniD· 2 shared Mélanie H. ThomasiD· 2 shared Sergio HelguetaiD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersNeuroscience

Manuel ButtiniORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 18, 2025

Transcriptional Dysregulation in the Hippocampus of a murine model for Parkinson's Disease Cognition Impairment is Driven by Sex, Age, and Alpha-synuclein overexpression

Alessia Sciortino, Thomas Hentrich, Sergio Helgueta…·Manuel Buttini

1 citation

mousebulk RNA-seq

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Molecular BiologybioRxivPreprintFeb 23, 2024

Park7 deletion leads to age- and sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes

Sergio Helgueta, Tony Heurtaux, Alessia Sciortino…·Lasse Sinkkonen

The paper shows that Park7 deletion causes sex-specific transcriptome changes in male mouse midbrain astrocytes via the NRF2-CYP1B1 axis, affecting oxidative stress and EMT processes.

DOI 10.1101/2024.02.23.581743

mousebulk RNA-seq

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NeurosciencebioRxivPreprintMar 21, 2022

Dietary fibre deprivation and bacterial curli exposure shift gut microbiome and exacerbate Parkinson's disease-like pathologies in an alpha-synuclein-overexpressing mouse

Kristopher J. Schmit, Alessia Sciortino, Velma T. E. Aho…·Paul Wilmes

This study shows that dietary fibre deprivation and bacterial curli exposure worsen PD-like symptoms in mice overexpressing human alpha-synuclein.

2 citations

mouseexperimental assay

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NeuroscienceMolecular NeurobiologyPeer-reviewedSep 30, 2020

A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease

Diana M. Hendrickx, Pierre Garcia, Amer Ashrafi…·Enrico Glaab

This study uses a synuclein-transgenic mouse model to identify molecular changes in early Parkinson's disease before neurodegeneration occurs.

10 citations

mousebulk RNA-seq

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