Jo Kate Perry

This study shows TNF-α induces different cell cycle gene responses in promyelocytic and granulocytic HL-60/S4 cells, with promyelocytes showing upregulation and granulocytes downregulation, and granulocytes shifting towards a macrophage-like transcriptome.

The paper uses Hi-C and RNA-seq to identify and compare structural variants in HL-60 and HL-60/S4 cell lines, finding novel SVs and differences in their stability.

The paper shows that neutrophil migration through small pores disrupts inactive chromatin organization, as revealed by transcriptomic and Hi-C analyses.

This study identifies immune regulatory networks influenced by T1D-associated genetic variants using 3D genome organization and gene expression data.