This study shows that cancer cachexia in Drosophila reduces sex-specific differences in gene expression and metabolic profiles, leading to a shared molecular cachexic state.

bioRxiv · Oct 15, 2026 · PreprintDevelopmental Biology

The pleiotropic functions of Pri smORF peptides synchronise leg development regulators

Damien Markus, Aurore Pelletier, Muriel Boube, Fillip Port, Michael Boutros, François Payre, Benedikt Obermayer, Jennifer Zanet

The paper identifies Pri smORF peptides as pleiotropic regulators of leg development in Drosophila, functioning through Ubr3-dependent and -independent mechanisms in patterning and cell survival.

bioRxiv · Mar 7, 2023 · PreprintDevelopmental Biology

Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

Jerome G. Bohere, Alexandra Mancheno-Ferris, Sandy Al Hayek, Jennifer Zanet, Philippe Valenti, Kohsuke Akino, Yuya Yamabe, Sachi Inagaki, Hélène Chanut-Delalande, Serge Plaza, Yuji Kageyama, Dani Osman, Cédric Polesello, François Payre

This study identifies Shavenbaby as a novel Hippo pathway effector critical for adult stem cell survival by activating DIAP1 to prevent apoptosis in Drosophila renal stem cells.

Nature Communications · Nov 26, 2018Peer-reviewedDevelopmental Biology