Kristin Reiche

A CAR T cell-amplified suppressive B cell circuit in AML

The paper identifies suppressive atypical memory B cells in AML that are amplified by CAR T cell interactions and shows that targeting both B cells and AML blasts can overcome this suppression.

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways

The paper develops a systems immunotoxicology workflow to model and predict adverse outcomes in immunotoxicology using a molecular interaction model and the MINERVA Platform.

Community assessment of methods to deconvolve cellular composition from bulk gene expression

The paper evaluates deconvolution methods for inferring immune infiltration from bulk gene expression using a DREAM Challenge, finding that some community-contributed methods, especially deep learning-based ones, perform well.

A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation

The paper identifies time-resolved gene expression profiles during T-cell activation using meta-analysis and validates them in CAR T-cell data.

uap: Reproducible and Robust HTS Data Analysis

The paper introduces uap, a workflow management system for reproducible and robust HTS data analysis, addressing reproducibility challenges in complex bioinformatic pipelines.