Katherina Sewald

N-acylethanolamine acid amidase inhibition reduces SARS-CoV-2 infection in Human Precision cut-lung slices and downregulates NF-kappaB signalling.

This study shows that inhibiting NAAA reduces SARS-CoV-2 replication in human lung tissue and suppresses NF-kappaB signaling.

Telomerase modRNA offers a novel RNA-based approach to treat human pulmonary fibrosis

This study demonstrates that modRNA hTERT treatment reduces fibrosis markers and senescence in human lung cells and tissue slices.

AMPK/ULK1 activation downregulates TXNIP, Rab5, and Rab7 and inhibits endocytosis-mediated entry of human pathogenic viruses

This study shows that AMPK/ULK1 activation inhibits endocytosis and blocks viral entry by reducing key endocytic factors and endosomal markers.

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways

The paper develops a systems immunotoxicology workflow to model and predict adverse outcomes in immunotoxicology using a molecular interaction model and the MINERVA Platform.

A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation

The paper identifies time-resolved gene expression profiles during T-cell activation using meta-analysis and validates them in CAR T-cell data.

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2

The paper screens approved drugs for SARS-CoV-2 inhibition and finds Fluoxetine significantly inhibits the virus at low concentrations, with no effect on other viruses.