Jonathan Baxter

Condensin chromatin association is regulated by SMC head and hinge engagement and phosphorylation

This study investigates how ATP binding, hinge stability, and phosphorylation regulate condensin chromatin association in budding yeast using ChIP assays and kinase activity analysis.

The Fork Protection Complex protects long replicons from DNA damage at the cost of genome instability induced by DNA topological stress.

This study shows that the Fork Protection Complex reduces DNA damage in regions prone to topological stress but increases genome instability in long replicons by promoting rapid replication.

Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress.

This study shows that Tof1/Timeless has distinct functions in DNA replication checkpoint signaling and replisome stability through separate regions of the protein.

Principles of Meiotic Chromosome Assembly

This study investigates meiotic chromosome assembly in yeast, revealing cohesin-dependent Hi-C patterns and the role of convergent transcription in shaping chromosome organization.

Cohesin dependent compaction of mitotic chromosomes

This study investigates the roles of cohesin and condensin in mitotic chromosome organization in budding yeast using Hi-C and polymer modeling, revealing distinct functions for each complex.