Matthew J. Neale

The paper shows that Top3 activity moves Holliday junctions from Spo11 hotspots to convergent transcription sites, where crossover resolution occurs during meiosis.

The paper models how Tel1-mediated feedback shapes Spo11-DSB formation in yeast, showing local inhibition leads to genome-wide DSB redistribution.

The paper shows that extending meiotic prophase reduces DSB clustering by allowing chromosomal domains to reach similar Spo11-DSB potential.

The paper introduces an optimized Hi-C protocol, Hi-C2B, for studying chromosomal contacts in synchronized meiotic S. cerevisiae cells, improving reproducibility and reducing noise.

The paper introduces CC-seq, a method to map Spo11 DNA double-strand breaks with nucleotide-resolution in S. cerevisiae meiotic cells.

The paper shows that absence of Red1 and Hop1 recruitment prevents meiotic recombination on a chromosome arm containing the sex locus in Lachancea kluyveri, affecting genome evolution and fitness.

The paper shows that mismatch repair (MMR) suppresses meiotic class I crossovers (COs) at regions of high sequence divergence in yeast, linking MMR to CO distribution and speciation.

The paper shows that DNA double-strand breaks (DSBs) during meiosis often occur in clusters with periodic spacing, challenging the idea that DSBs are isolated events.

The paper maps Top2-linked DNA breaks with nucleotide resolution in yeast and human genomes, revealing distinct activity fractions and sequence influences on cleavage.

This study investigates meiotic chromosome assembly in yeast, revealing cohesin-dependent Hi-C patterns and the role of convergent transcription in shaping chromosome organization.

This study shows TDP2 can remove Spo11 from Spo11-DSBs in vitro but not in vivo, suggesting structural barriers prevent TDP2 access to Spo11-DNA in living cells.

This study investigates the distinct roles of Mec1 and Rad24 in meiotic recombination, showing that Mec1 affects DSB trans-interference and CO pathway distribution, while Rad24 influences interference through CO number reduction.