Andrea Keszthelyi

This study shows that the Fork Protection Complex reduces DNA damage in regions prone to topological stress but increases genome instability in long replicons by promoting rapid replication.

This study shows that Tof1/Timeless has distinct functions in DNA replication checkpoint signaling and replisome stability through separate regions of the protein.

The paper shows that disrupting dNTP homeostasis is synthetically lethal with CDK-induced replication stress in fission yeast, leading to genome instability and cell death.