Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis
Shoshanna C. Kahne, Jin Hee Yoo, James Chen, Kehilwe C. Nakedi, Lakshminarayan M. Iyer, Gregory Putzel, Nora M. Samhadaneh, Alejandro Pironti, L. Aravind, Damian C. Ekiert, Gira Bhabha, Kyu Young Rhee, K. Heran Darwin
The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.
Proceedings of the National Academy of Sciences · Nov 25, 2024Peer-reviewedMicrobiology