Melissa R. Pergande

This study identifies molecular pathways and regulatory programs associated with hPSC-CM maturation through multi-omic profiling during long-term culture.

This paper uses mass spectrometry-based multiomic profiling to analyze proteome, lipidome, and metabolome changes in IFN-γ and LPS-stimulated BV-2 microglial cells, revealing coordinated immune, lipid, and metabolic adaptations.

The paper identifies ssTnI overexpression as enhancing cardiomyocyte proliferation and regenerative capacity post-MI through metabolic shifts.

This paper shows that neurofilament accumulation in GAN disrupts autophagy through impaired organelle distribution and sequestration of 14-3-3, affecting TFEB localization.

This paper presents a comprehensive metabolomic analysis of human heart tissue using parallel extraction methods and high-resolution mass spectrometry to identify 2276 metabolites across a wide range of polarities.

This study develops a method to analyze the human lung ECM proteome using photocleavable surfactant and diaPASEF, identifying nearly 400 unique matrisome proteins.

MASH Native provides a unified software solution for processing native top-down proteomics data, offering database searching and analysis tools in a user-friendly interface.