Chunaram Choudhary

The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation

The paper identifies the SPATA5-SPATA5L1-CINP-C1ORF109 complex as essential for pre-60S ribosome maturation and shows its evolution from yeast Drg1.

Modeling nascent transcription from chromatin landscape and structure

The paper introduces CLASTER, a deep learning model that predicts nascent transcription levels from chromatin landscape and 3D structure data, achieving high correlation with experimental measurements.

A unified model of gene expression control by cohesin and CTCF

This study shows cohesin and CTCF regulate gene expression through both architectural and direct transcriptional mechanisms, with CTCF also acting as a transcriptional activator independent of cohesin.

Mammalian enhancers and GWASs act proximally and seldom skip active genes

The paper investigates enhancer-promoter interactions and finds that gene-skipping enhancers are rare, with proximity and coactivator dependency better predicting functional relationships.

TOBF1 modulates mouse embryonic stem cell fate through co-transcriptional regulation of alternative splicing

This study identifies TOBF1 as a regulator of alternative splicing in mouse embryonic stem cells, showing its role in maintaining stem cell identity through co-transcriptional mechanisms.

A unique H2B acetylation signature marks active enhancers and predicts their target genes

The paper identifies H2B acetylation as a marker for active enhancers and shows it predicts enhancer target genes better than existing methods.

The logic of native enhancer-promoter compatibility and cell-type-specific gene expression variation

The paper investigates how native enhancers interact with promoters to shape cell-type-specific gene expression and shows that enhancers can regulate both developmental and housekeeping genes.

Higher eukaryote-specific APC/C composition is a determinant of spindle assembly checkpoint importance

This study shows that specific APC/C subunits APC7 and APC16 influence the importance of the spindle assembly checkpoint by affecting synthetic viability when MAD2 is deleted.