Enhanced PIEZO1 Function Contributes to the Pathogenesis of Sickle Cell Disease
Luis O. Romero, Manisha Bade, Laila Elsherif, Jada D. Williams, Xiangmei Kong, Adebowale Adebiyi, Kenneth I. Ataga, Shang Ma, Julio F. Cordero-Morales, Valeria Vásquez
This study shows that enhanced PIEZO1 function in sickle erythrocytes contributes to hemolysis and inflammation in SCD, and that EPA diet reduces PIEZO1 activity and ameliorates disease symptoms.
Proceedings of the National Academy of Sciences · Oct 2, 2025Peer-reviewedPhysiology