Yonghe Ding

This study uses zebrafish mutants to identify genetic modifiers of kidney cysts, finding that mtor and ulk1a inhibition can reverse cyst-related abnormalities.

The paper identifies an mTOR-Tfeb-Fabp7a signaling pathway that can repair proteostasis defects and cardiac dysfunction in zebrafish BAG3 cardiomyopathy.

This paper presents a zebrafish model of Leigh Syndrome, demonstrating liver dysfunction's critical role in mitochondrial disease through genetic rescue.

This study identifies Dnajb6 as a gene causing sick sinus syndrome through a phenotype-based genetic screen in zebrafish.

The paper presents a collection of zebrafish genetic mutants for studying mitochondrial biology and disease.

The paper identifies SORBS2 as a new susceptibility gene for arrhythmogenic right ventricular cardiomyopathy (ARVC) using zebrafish and mouse models and human patient sequencing.

The paper describes a zebrafish gene break transposon library for genomic discovery and disease modeling, identifying novel gene expression patterns and generating models for human disease loci.

This study identifies RXRA as a therapeutic target for doxorubicin-induced cardiomyopathy in zebrafish by showing its endothelial-specific function and response to FDA-approved agonists.