Author

Jean Vacher

Montreal Clinical Research InstituteORCID 0000-0002-4560-3476Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

Amir Pri-Or· 1 shared Ari ElsoniD· 1 shared Benjamin GeigeriD· 1 shared Brinda Kizhakke VallatiD· 1 shared Christian S. HinrichsiD· 1 shared Francesco BertoniiD· 1 shared Giuseppe Caso· 1 shared Haowei LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

Amir Pri-Or

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2 papers

Recent·Most cited

OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway

Muhammad Usama Tariq, Namratha Sheshadri, Jianliang Shen, Jaeyong Jung, Haowei Li, Kevin Lu, Junrong Yan, Mark C. Koch, Giuseppe Caso, Hassan Sajjad, Brinda Kizhakke Vallat, Stephen Kevin Burley, Yi Sun, Tong Liu, Hong Li A, , Wei Zong

This study identifies OSTM1 as a tumor suppressor in B-cell malignancies by showing it activates the cAMP/PKA/CREB pathway through ubiquitin E3 ligase activity.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

The molecular and cellular interplay between the osteopetrosis-associated proteins SNX10, OSTM1, and CLC-7 during osteoclastogenesis

Nina Bacher Reuven, Sabina E. Winograd-Katz, Maayan Barnea, Amir Pri-Or, Yishai Levin, Jean Vacher, Benjamin Geiger, Ari Elson

This study investigates the molecular interactions between SNX10, CLC-7, and OSTM1 in osteoclasts, showing they regulate lysosome distribution and fusion during osteoclastogenesis.

bioRxiv · Mar 31, 2025 · PreprintCell Biology