Rodrigo O. Sierra

A selective cortico-limbic network organizes behavior during reward seeking under threat

This study identifies a selective cortico-limbic network involved in resolving motivational conflict during reward seeking under threat by inactivating brain regions in rats.

Hippocampal sharp wave ripples mediate generalization and subsequent fear attenuation via closed-loop brain stimulation in rats

This study shows that closed-loop brain stimulation targeting the amygdala or prefrontal cortex after fear memory reconsolidation reduces fear generalization and enhances extinction in rats.

Closed-loop brain stimulation to reduce pathologic fear

This study shows that closed-loop brain stimulation using hippocampal sharp wave-ripples can enhance fear extinction memory consolidation and reduce pathologic fear in a PTSD model.

Conflict-mediated tasks for studying the act of facing threats in pursuit of rewards

This paper develops three conflict-mediated tasks to study how rats balance threats and rewards, finding that low-dose diazepam facilitates reward-seeking despite threats.