Che Yang

Mapping targetable sites on the human surfaceome for the design of novel binders

The paper identifies 4,500 targetable sites on the human surfaceome and introduces binder seeds for protein design, validated through experimental approaches and supported by a database.

A generic framework for hierarchical de novo protein design

This paper introduces a framework for de novo protein design that automatically generates structural templates and evaluates their stability through experimental characterization.

Rosetta FunFolDes - a general framework for the computational design of functional proteins

This paper introduces a computational framework for designing functional proteins by integrating folding and sequence design, showing that functional motifs can be embedded without requiring the global energy minimum.