Author

Ta-Yi Yu

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Aditya KrishnakumariD· 2 shared David A. BakeriD· 2 shared Divij MathewiD· 2 shared E. John WherryiD· 2 shared Marc ExpòsitiD· 2 shared Mohamad H. AbediiD· 2 shared Sophie L. Gray-GaillardiD· 2 shared Ahmed SadekiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersSynthetic Biology

Aditya KrishnakumarORCID

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Author profile →

3 papers

Recent·Most cited

Mapping targetable sites on the human surfaceome for the design of novel binders

Petra E. M. Balbi, Ahmed Sadek, Anthony Marchand, Ta-Yi Yu, Jovan Damjanovic, Sandrine Georgeon, Joseph H. Schmidt, Simone Fulle, Che Yang, Hamed Khakzad, Bruno E. Correia

The paper identifies 4,500 targetable sites on the human surfaceome and introduces binder seeds for protein design, validated through experimental approaches and supported by a database.

Proceedings of the National Academy of Sciences · Jan 28, 2026Peer-reviewedSynthetic Biology

High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists

Mohamad H. Abedi, Marc Expòsit, Brian Coventry, Divij Mathew, Shruti Jain, Aditya Krishnakumar, Inna Goreshnik, Sophie L. Gray-Gaillard, Margaret C. Lunn-Halbert, Ta-Yi Yu, Matthias Glögl, Uma Mitchell, Riya Keshri, Jung-Ho Chun, Hannele Ruohola‐Baker, , David A. Baker

The paper designs novel cytokines by fusing computationally generated receptor-binding domains, identifying several that activate signaling pathways and have specific biological effects.

bioRxiv · Oct 12, 2025 · PreprintSynthetic Biology

Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling

Marc Expòsit, Mohamad H. Abedi, Aditya Krishnakumar, Shruti Jain, Ta-Yi Yu, Timothy R. Hercus, Divij Mathew, Sophie L. Gray-Gaillard, Zhijie Chen, William S. Grubbe, Andrew Favor, Winnie L. Kan, Thomas Schlichthaerle, Wei Chen, Michael W. Parker, , David A. Baker

This paper designs synthetic cytokine agonists with controlled receptor geometry to modulate signaling outcomes and functional effects.

bioRxiv · Oct 12, 2025 · PreprintSynthetic Biology