Author

Sarah Wehrle

SIB Swiss Institute of Bioinformatics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

Bruno E. CorreiaiD· 3 shared Andreas ScheckiD· 2 shared Corey P. MallettiD· 2 shared Karla M. CastroiD· 2 shared Sandrine GeorgeoniD· 2 shared Stéphane RossetiD· 2 shared Thomas KreyiD· 2 shared Ventzislav B. VassileviD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Bruno E. CorreiaORCID

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Author profile →

4 papers

Recent·Most cited

Predicting TCR antigen specificity at proteome-scale with synthetic immune cells and machine learning

Kai‐Lin Hong, Beichen Gao, Lucas Stalder, Roy A. Ehling, Marton Horvath, Sarah Wehrle, Juliette L. Forster, Valentin Junet, Jakub Kucharczyk, Sébastien Lalevée, Marie‐Charlotte Diringer, Qinmei Yang, Rodrigo Vazquez-Lombardi, Sai T. Reddy

The paper presents a synthetic immune cell platform integrated with machine learning to predict TCR specificity to peptide-HLA antigens across the human proteome.

bioRxiv · Jul 23, 2025 · PreprintImmunology

Computationally designed stem-epitope mimetics elicit broadly reactive antibodies

Sarah Wehrle, Andreas Scheck, Laura Reusch, Flavio Lemos Matassoli, Sandrine Georgeon, Karla M. Castro, Johannes Cramer, Wayne D. Harshbarger, Stéphane Rosset, Sarah F. Andrews, Karin Schön, Badiaa Bouzya, Ronan Nicolas Rouxel, Normand Blais, E. Malito, , Bruno E. Correia

This study designs stem-epitope mimetics using computational methods to elicit broadly reactive antibodies against influenza viruses.

bioRxiv · Jan 22, 2025 · PreprintBiochemistry

Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity

Karla M. Castro, Reyhaneh Ayardulabi, Sarah Wehrle, Hongrui Cui, Sandrine Georgeon, Joseph H. Schmidt, Shuhao Xiao, Nishat Seraj, Wayne D. Harshbarger, Corey P. Mallett, Ventzislav B. Vassilev, Xavier Saelens, Bruno E. Correia

This paper designs chimeric influenza hemagglutinins that combine antigenic surfaces from different strains to elicit cross-group immunity and neutralize multiple strains.

bioRxiv · Dec 17, 2024 · PreprintBiochemistry

Rosetta FunFolDes - a general framework for the computational design of functional proteins

Jaume Bonet, Sarah Wehrle, Karen Schriever, Che Yang, Anne Billet, Fabian Sesterhenn, Andreas Scheck, Freyr Sverrisson, Barbora Veselková, Sabrina S. Vollers, Roxanne Lourman, Mélanie Villard, Stéphane Rosset, Thomas Krey, Bruno E. Correia

This paper introduces a computational framework for designing functional proteins by integrating folding and sequence design, showing that functional motifs can be embedded without requiring the global energy minimum.

PLoS Computational Biology · Nov 19, 2018Peer-reviewedBioinformatics