Karen Schriever

The paper screens variants of a Form II Rubisco to improve oxygen tolerance, identifies key mutations, and uses a transformer model to guide engineering.

The paper identifies metabolite-protein interactions in the Calvin cycle of cyanobacteria and lithoautotrophic bacteria, revealing species-specific regulation and feed-forward activation mechanisms.

This paper introduces a computational framework for designing functional proteins by integrating folding and sequence design, showing that functional motifs can be embedded without requiring the global energy minimum.