Author

Edwin Ramos Manuel

Beckman Research InstituteORCID 0000-0002-4602-7060Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Lara C. AvsharianiD· 2 shared Nancy D. EbeltiD· 2 shared Suvithanandhini LoganathaniD· 2 shared Katarzyna DąbrowskaiD· 1 shared Khyatiben V. PathakiD· 1 shared Nathaniel Fox Hansen· 1 shared Patrick PirrotteiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Lara C. AvsharianORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Precision Targeting of Heparan Sulfate Proteoglycans Broadly Dysregulates Survival Signaling and Metabolic Adaptation in Pancreatic Cancer

Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Katarzyna Dąbrowska, Nathaniel Fox Hansen, Khyatiben V. Pathak, Patrick Pirrotte, Edwin Ramos Manuel

This study shows that targeting heparan sulfate proteoglycans in pancreatic cancer with bacterial heparinase III reduces survival signaling and metabolic adaptation, potentially improving therapy efficacy.

bioRxiv · Oct 5, 2026 · PreprintCancer Biology

Effects of Hypomethylating Agents on Gene Modulation in the Leukemic Microenvironment and Disease Trajectory in a Mouse Model of AML

Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Edwin Ramos Manuel

This study examines how hypomethylating agents affect gene expression in non-leukemic cells in a mouse model of AML, identifying novel gene targets and pathways involved in treatment response and relapse.

bioRxiv · Dec 1, 2024 · PreprintCancer Biology