Author

Lara C. Avsharian

City Of Hope National Medical CenterORCID 0009-0005-7287-8650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Edwin Ramos ManueliD· 2 shared Nancy D. EbeltiD· 2 shared Suvithanandhini LoganathaniD· 2 shared Ashni A. Vora· 1 shared Dorota Skowronska‐KrawczykiD· 1 shared Fangyuan GaoiD· 1 shared Hojun LiiD· 1 shared Joshua D. HartmaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

Edwin Ramos ManuelORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 5, 2026

Precision Targeting of Heparan Sulfate Proteoglycans Broadly Dysregulates Survival Signaling and Metabolic Adaptation in Pancreatic Cancer

Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian…·Edwin Ramos Manuel

This study shows that targeting heparan sulfate proteoglycans in pancreatic cancer with bacterial heparinase III reduces survival signaling and metabolic adaptation, potentially improving therapy efficacy.

DOI 10.64898/2026.10.01.756059

humanexperimental assay

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Cell BiologyGeroSciencePeer-reviewedApr 15, 2025

Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development

Silvia Vicenzi, Fangyuan Gao, Parker Côté…·Leslie A. Crews

This study identifies ELOVL2 as a key lipid metabolism enzyme that regulates B cell progenitor development and immune aging in mice and humans.

6 citations

mousehuman

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Cancer BiologybioRxivPreprintDec 1, 2024

Effects of Hypomethylating Agents on Gene Modulation in the Leukemic Microenvironment and Disease Trajectory in a Mouse Model of AML

Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Edwin Ramos Manuel

This study examines how hypomethylating agents affect gene expression in non-leukemic cells in a mouse model of AML, identifying novel gene targets and pathways involved in treatment response and relapse.

1 citation

mousebulk RNA-seq

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