BiochemistryNature Chemical BiologyPeer-reviewed
Allosteric Disordering of eIF2B Regulates the Integrated Stress Response
Udit Dalwadi, Advait Subramanian, Aniliese Deal…·Adam S. Frost
This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.
2 citations