Adam S. Frost

This study identifies ARMC1 as a regulator of mitochondrial fatty acid oxidation through its interaction with MTCH2, showing that this interaction suppresses FAO during starvation.

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

This study shows progerin causes nuclear envelope remodeling in two stages, with NUP153 promoting invagination, and links these changes to aging-related nuclear morphology.

This paper compares multislice projections of MD simulations with cryoEM to identify structural prediction errors in coarse-grained and all-atom MD simulations of membranes.

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

This study investigates how cardiolipin dynamics influence mitochondrial membrane remodeling via OPA1 interactions using molecular dynamics and cryoEM.

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.

The paper shows how a point mutation in eIF2B's β subunit mimics eIF2-P binding, leading to constitutive activation of the integrated stress response through an I-State conformation.

The paper identifies GIGYF2 and 4EHP as translation inhibitors that suppress re-initiation of defective mRNAs, aiding ribosome-associated quality control and preventing toxic protein accumulation.