Author

Aniliese Deal

Altos LabsORCID 0000-0002-3041-3653Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Adam S. FrostiD· 2 shared Christopher P. ArthuriD· 2 shared D. John LeeiD· 2 shared Mauro Costa‐MattioliiD· 2 shared Morgane BooneiD· 2 shared Pascal F. EgeaiD· 2 shared Peter WalteriD· 2 shared Rosalie E. LawrenceiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

Adam S. FrostORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolutionary insights into an ancient fungal transition from land to sea

Kaylee E. Christensen, Aniliese Deal, Rachel B. Brem

This study investigates the evolutionary transition of fungi from land to sea using Kluyveromyces yeasts, finding genome size reduction, phenotypic changes, and positive selection in marine species.

bioRxiv · Oct 16, 2026 · PreprintEvolutionary Biology

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

Udit Dalwadi, Advait Subramanian, Aniliese Deal, Julia E. Conrad, Tamara Nadjsombati, Meera Venkatesh, Morgane Boone, Pascal F. Egea, Ling-jie He, Nimit Jain, D. John Lee, Yuwei Liu, Lucas Charles Reineke, Kazuki Saito, Nathaniel Talledge, , Adam S. Frost

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

Nature Chemical Biology · Jun 29, 2026Peer-reviewedBiochemistry

Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer

Morgane Boone, Udit Dalwadi, Aniliese Deal, Ping Zhu, Tristan Ian Croll, Maya Yamazaki, Kimberly Prescott, Renato Minopoli, Isabella Biscocho, Junhua Wang, D. John Lee, Christopher P. Arthur, Thomas G. Laughlin, Hongyi Zhou, Matthew T. Klope, , Peter Walter

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

bioRxiv · Feb 7, 2026 · PreprintBiochemistry