Matteo Elia Mangoni

Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate

This study shows endurance exercise increases proarrhythmic remodeling in pulmonary vein sleeve myocytes and the PV-LA junction, contributing to atrial fibrillation susceptibility in athletes.

Resident cardiac macrophages are not required for normal atrioventricular node conduction

This study challenges the role of resident cardiac macrophages in AV node conduction by showing no evidence of Cx43-mediated coupling and no effect of macrophage depletion on AV electrical activity.

Validation of differentiated sinoatrial-like hiPSCs as a model of native sinus node myocytes

The paper validates a protocol to generate sinoatrial-like hiPSC-derived cardiomyocytes that mimic native SAN myocytes in function and protein expression.

The expression level of CACNA1C-encoded CaV1.2 is a tipping point between promotion and inhibition of dendritic growth in neurons

The paper shows that CaV1.2 expression level determines whether calcium currents promote or inhibit dendritic growth in neurons, with implications for psychiatric disorders.

Abnormal autonomic regulation of heart rate underlies age-related and sexdependent cardiac dysfunction in the small primate Microcebus murinus.

This study examines age-related and sex-dependent cardiac dysfunction in Microcebus murinus by analyzing heart rate and variability under stress and autonomic modulation.

A new perspective on slow pacemaking in brain and heart

The paper identifies a conserved voltage-dependent pacemaker current essential for slow firing in neurons and cardiac cells, confirmed by models and experiments.

Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction

This study identifies a recombinant nanobody that specifically activates HCN4 channels and rescues sinus node dysfunction in a patient with a loss-of-function mutation.

T-type calcium channels participate in intrinsic and synaptic activity of PKCγ neurons of the dorsal horn of the spinal cord during chronic pain

This study investigates the role of T-type calcium channel Cav3.2 in PKCγ neurons of the spinal dorsal horn during chronic pain, showing its involvement in synaptic and intrinsic activity changes but not in firing properties.