Author

Kimberle Shen

Agency for Science, Technology and Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Organism:zebrafish· 2

Frequent Co-Authors

Wei Leong ChewiD· 2 shared Amine MelianiiD· 1 shared Ana M. MeirelesiD· 1 shared Anand Kumar AndiappaniD· 1 shared Ashley L. St. JohniD· 1 shared Bolun WangiD· 1 shared Caroline Lei WeeiD· 1 shared Chao LiangiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

Wei Leong ChewORCID

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4 papers

Recent·Most cited

Spatial Perturb-Seq: Single-Cell Functional Genomics within Intact Tissue Architecture

Kimberle Shen, Wan Yi Seow, Choong Tat Keng, Michelle Gek Liang Lim, Daryl Shern Lim, Ke Guo, Amine Meliani, Muhammad Irfan Bin Hajis, Bolun Wang, Shyam Prabhakar, Kok Hao Chen, Wei Leong Chew

This paper introduces Spatial Perturb-Seq, a CRISPR-based method to screen genes in intact tissues, revealing gene effects on neuronal communication in mouse brains.

Nature Communications · Feb 21, 2026Peer-reviewedCell Biology

Reduced Complex III assembly dampens host inflammation as an adaptive response to viral infection

Sheryl Beh, Cheryl Q. E. Lee, Kimberle Shen, Chengwei Zhong, Chinmay Kumar Mantri, Chao Liang, Radiance Lim, Tan Kiat Yi, Radoslaw Mikolaj Sobota, Jinmiao Chen, Ashley L. St. John, Lena Ho

This study shows that reducing Complex III in macrophages during viral infection dampens inflammation, improving recovery from H1N1 influenza.

bioRxiv · Feb 5, 2026 · PreprintImmunology

Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

Vindhya Chaganty, Ruey‐Kuang Cheng, Kimberle Shen, Na Zhang, Gaynah Javier Doblado, Sarah Ong, Sandra Tan, Valarie Yu Yan Tham, Jung-Hwa Choi, Marnie E. Halpern, Wei Leong Chew, Anand Kumar Andiappan, Sarah Xinwei Luo, Caroline Lei Wee

The paper identifies conserved GABAergic neurons in zebrafish and mouse lateral hypothalamus that respond to growth hormone and food cues, revealing a shared mechanism for appetite regulation.

Molecular Metabolism · Sep 13, 2025Peer-reviewedNeuroscience

Repression of lysosomal transcription factors Tfeb and Tfe3 is essential for the migration and function of microglia

Harini Iyer, Kimberle Shen, Ana M. Meireles, William S. Talbot

This study shows that repression of Tfeb and Tfe3 is essential for microglia migration and function by regulating lysosomal activity in zebrafish.

bioRxiv · Oct 27, 2020 · PreprintDevelopmental Biology