E3 Ligase Ligandalyzer provides a platform for exploring E3 ligase-recruiter complexes, enabling analysis of chemical and structural data to support degrader design.

bioRxiv · Oct 14, 2026 · PreprintBioinformatics

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription

Gary LeRoy, Ozgur Oksuz, Nicolas Descostes, Yuki Aoi, Rais A. Ganai, Havva Ortabozkoyun, Jia-Ray Yu, Chul‐Hwan Lee, James M. Stafford, Ali Shilatifard, Danny Reinberg

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.

Science Advances · Oct 2, 2019Peer-reviewedMolecular Biology

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

James M. Stafford, Chul‐Hwan Lee, Philipp Voigt, Nicolas Descostes, Ricardo Saldaña-Meyer, Jia-Ray Yu, Gary LeRoy, Ozgur Oksuz, Jessica R. Chapman, Fernando Suarez, Aram Sandaldjian Modrek, Nermin Sumru Bayin, Dimitris G. Placantonakis, Matthias A. Karajannis, Matija Snuderl, , Danny Reinberg

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.

Science Advances · Oct 5, 2018Peer-reviewedMolecular Biology

Automethylation of PRC2 fine-tunes its catalytic activity on chromatin

Chul-Hwan Lee, Jeffrey Granat, Jia-Ray Yu, Gary LeRoy, James Stafford, Danny Reinberg

This study identifies PRC2 automethylation on EZH1/2 and SUZ12 as a self-activating mechanism that regulates its catalytic activity on chromatin.

bioRxiv · Jun 17, 2018 · PreprintBiochemistry

Capturing the onset of PRC2-mediated repressive domain formation

Ozgur Oksuz, Varun K. Narendra, Chul‐Hwan Lee, Nicolas Descostes, Gary LeRoy, Ramya Raviram, Lili M. Blumenberg, Kelly R. Karch, Pedro P. Rocha, Benjamin Aaron Garcia, Jane A. Skok, Danny Reinberg

The paper demonstrates a two-step mechanism of PRC2-mediated repressive domain formation through nucleation sites and long-range spreading of H3K27me2/3.

Molecular Cell · Jun 1, 2018Peer-reviewedGenomics