BiophysicsAnnals of the Rheumatic DiseasesPeer-reviewed
Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis
YanHua Xiao, Xuezhi Hong, Langxian Zhi…·Alexandru-Emil Matei
This study uses blood vessel organoids to model systemic sclerosis vasculopathy and fibrosis, showing that SSc serum induces epigenetic and molecular changes linked to endothelial dysfunction and potential therapeutic targets.
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