Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis
YanHua Xiao, Xuezhi Hong, Langxian Zhi, Yi-Nan Li, Martin Regensburger, Franz Marxreiter, Boris Görg, Sarah Koziel, Andrea‐Hermina Györfi, Tim Filla, Peter‐Martin Bruch, Philipp Tripal, James Adjaye, Sascha Dietrich, Jürgen Winkler, , Alexandru-Emil Matei
This study uses blood vessel organoids to model systemic sclerosis vasculopathy and fibrosis, showing that SSc serum induces epigenetic and molecular changes linked to endothelial dysfunction and potential therapeutic targets.
Annals of the Rheumatic Diseases · Mar 22, 2026Peer-reviewedBiophysics