Bakhtiyor Nosirov

Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma

The paper identifies impaired monocyte states and trajectories in glioblastoma patients through immune profiling, revealing systemic immune reprogramming and potential therapeutic targets.

TAOK3 inhibition constrains invasion, potentiates paclitaxel, and reprograms the tumor microenvironment toward anti-tumor immunity in cervical cancer

This study shows TAOK3 inhibition reduces cervical cancer invasion, increases paclitaxel sensitivity, and promotes anti-tumor immunity by altering the tumor microenvironment.

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas

This study integrates multi-omics and functional drug screening in patient-derived organoids to identify personalized therapeutic vulnerabilities in adult high-grade gliomas, finding distinct drug responses in IDH1 mutant and MYCN-amplified tumors.