Brian D. Marsden

Neuroanatomically Derived Genetic Representations Enhance Detection of Plasma Protein Associations

This study uses brain-genotype scores to identify genetic associations with plasma proteins, finding 116 significant associations after FDR correction that conventional SNP models miss.

Early regional lymph node activation drives influenza vaccine responses in an ancestrally diverse cohort

This study examines immune responses in ancestrally diverse individuals after influenza vaccination, finding that draining lymph nodes show rapid activation and specific cellular changes.

INTERPOLATION-BASED CONDITIONING OF FLOW MATCHING MODELS FOR BIOISOSTERIC LIGAND DESIGN

The paper introduces two conditioning strategies for flow-matching models to generate bioisosteric 3D molecules without retraining, demonstrating effectiveness on drug-relevant tasks.

A validated antibody toolbox for ALS research

The paper establishes a validated antibody platform for ALS research, identifying high-quality antibodies and revealing protein expression patterns in neurological cell types.

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

MolSnapper: Conditioning Diffusion for Structure Based Drug Design

MolSnapper improves structure-based drug design by conditioning diffusion models with 3D pharmacophores, generating more valid molecules with higher structural and chemical similarity.

Robustly interrogating machine learning based scoring functions: what are they learning?

This study evaluates machine learning-based scoring functions by comparing them to baseline models that only learn dataset biases, revealing that the MLBSFs primarily capture biases rather than generalizable physics knowledge.

Integrative analysis of GWAS and co-localisation data suggests novel genes associated with age-related multimorbidity

The paper identifies 995 genes with shared genetic links to age-related diseases using GWAS data and presents them in a web tool for drug target prioritization.

SATurn: A modular bioinformatics framework for the design of robust maintainable web-based and standalone applications

SATurn is a modular bioinformatics framework for creating maintainable web and standalone applications, used to build a bioinformatics portal supporting diverse scientific research.