Sylvie Brochu

This study identifies YES and SRC tyrosine kinases as redundant drivers of MPNST and shows their inhibition suppresses tumor growth and reactivates immune responses.

This study develops a mouse model with targeted MHC I overexpression in alveolar type 2 cells, showing sustained upregulation without pathology and suggesting therapeutic potential.

This study shows MHC I expression is low in healthy human lung epithelial cells but increases in three chronic respiratory diseases, with males showing higher baseline levels due to sex-related redox differences.