Sylvain Meloche

This study identifies IL-17RD as a negative regulator of RIG-I-like receptor-dependent antiviral immunity, showing it limits SARS-CoV-2-induced lung inflammation.

This study identifies YES and SRC tyrosine kinases as redundant drivers of MPNST and shows their inhibition suppresses tumor growth and reactivates immune responses.

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

This study shows ERK3 promotes TNBC progression through EMT plasticity and collective migration, linking it to poor clinical outcomes.

The paper reevaluates ERK3's role using new mouse models, finding that ERK3 kinase activity is necessary for post-natal growth but not for perinatal survival.