Claude Perreault

This study identifies YES and SRC tyrosine kinases as redundant drivers of MPNST and shows their inhibition suppresses tumor growth and reactivates immune responses.

The paper identifies cryptic leukemia antigens that share homology with microbial epitopes and can stimulate T-cell responses in healthy donors, suggesting their potential as targets for T-cell-based immunotherapies.

This study develops a mouse model with targeted MHC I overexpression in alveolar type 2 cells, showing sustained upregulation without pathology and suggesting therapeutic potential.

This study shows MHC I expression is low in healthy human lung epithelial cells but increases in three chronic respiratory diseases, with males showing higher baseline levels due to sex-related redox differences.

The paper introduces CAMAP, an artificial neural network that predicts MHC-I peptide presentation by analyzing codon arrangement in mRNA sequences, improving prediction accuracy beyond traditional methods.